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the Case Study
Step 01
tHE idea
The Objective
The scientific journal editor proposes illustration services to authors who wish to publish in their peer-reviwed journal.
As scientific graphic designer, I then intervene to adapt the author's graphical abstract or figure to journal guidelines and style.
Step 02
tHE brief
CVR - Cardiovascular Research
Peer-reviewed journal - IF: 10.9
Journal style
Editor's guidelines include a precise format for the figure: 510.24 px x 510.24 px (formatted in cm).
Myriad Pro font is preferred and should not be smaller than 10 pt
Colors should be adapted for color-blind people:
elements that need to be identified or differentiated need to be seen by at least the most common types of color blindness (Protanopia and Deuteranopia).
A color palette has been defined in agreement with the editor.
Step 03
tHE abstract
The RAGE/DIAPH1 axis: mediator of obesity and proposed biomarker of human cardiometabolic disease
Overweight and obesity are leading causes of cardiometabolic dysfunction. Despite extensive investigation, the mechanisms mediating the increase in these conditions are yet to be fully understood. Beyond the endogenous formation of advanced glycation endproducts (AGEs) in overweight and obesity, exogenous sources of AGEs accrue through the heating, production, and consumption of highly processed foods. Evidence from cellular and mouse model systems indicates that the interaction of AGEs with their central cell surface receptor for AGE (RAGE) in adipocytes suppresses energy expenditure and that AGE/RAGE contributes to increased adipose inflammation and processes linked to insulin resistance. In human subjects, the circulating soluble forms of RAGE, which are mutable, may serve as biomarkers of obesity and weight loss. Antagonists of RAGE signalling, through blockade of the interaction of the RAGE cytoplasmic domain with the formin, Diaphanous-1 (DIAPH1), target aberrant RAGE activities in metabolic tissues. This review focuses on the potential roles for AGEs and other RAGE ligands and RAGE/DIAPH1 in the pathogenesis of overweight and obesity and their metabolic consequences.
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